The Sartorius BIA Separations Primas HR Monolithic Column (Catalog No. 911.5119-2) is an 80 mL preparative-scale convective interaction media (CIM) monolith built for high-performance downstream purification of complex biotherapeutics. Designed to bridge lab-scale process development and pilot-scale biomanufacturing, Primas HR leverages convective mass transfer to deliver exceptional speed, capacity and resolution for large, shear-sensitive biomolecules including AAV, lentivirus, plasmid DNA, VLPs and other viral vectors.

• Catalog Number: 911.5119-2

• Product Name: Primas HR Monolithic Column

• Brand: Sartorius (BIA Separations)

• Bed Volume: 80 mL

• Phase: CIM Convective Interaction Media monolith

• Format: Preparative / pilot scale pre-packed column

• Main Targets: AAV, lentivirus, pDNA, VLPs, viral vectors, large biomolecules

• Best For: Capture, polishing, process development, scale-up studies

• Compatible Systems: Pilot process chromatography skids, ÄKTA pure / pilot systems

Key Benefits

✅ Convective mass transfer supports high flow rates and fast purification cycles 

✅ Low backpressure at high linear velocities for higher batch throughput

 ✅ Gentle separation preserves fragile viral capsids and plasmid isoforms

 ✅ Reliable clearance of HCP, gDNA, RNA and endotoxin impurities 

✅ Smooth scale-up from CIMac analytical columns to CIMmultus production columns 

✅ Consistent performance for process development and method validation 

✅ Pre-packed, ready-to-use, eliminates in-house column packing variability

 ✅ Suitable for gene therapy, viral vector and nucleic acid bioprocess development