The Sartorius BIA Separations CIMmultus™ QAHR Monolithic Column (Catalog No. BIA‑924.5213‑2) is a cGMP-compliant, preparative-scale convective interaction media (CIM) monolith featuring quaternary amine (QA) strong anion-exchange chemistry. With a bed volume of 400 mL and 2 µm channel size, this pre-packed industrial column is purpose-built for capturing and polishing large biomolecules including plasmid DNA (pDNA), adeno-associated virus (AAV), lentivirus, mRNA, VLPs and other viral vectors used in gene therapy, cell therapy and nucleic acid vaccine production.

• Catalog Number: BIA‑924.5213‑2

• Product Name: CIMmultus™ QAHR Monolithic Column

• Brand: Sartorius (BIA Separations)

• Bed Volume: 400 mL

• Channel Size: 2 µm

• Stationary Phase: CIM Convective Interaction Media, Quaternary Amine (QA) strong anion exchange

• Compliance: cGMP compliant, full regulatory documentation package

• Format: Preparative / industrial manufacturing column

• Primary Targets: AAV, lentivirus, pDNA, mRNA, viral vectors, VLPs

• Compatible Systems: Industrial process chromatography skids, GMP bioprocess platforms

Key Benefits

✅ Strong quaternary amine anion exchange for robust binding of negatively charged large biomolecules

 ✅ Convective mass transfer enables high flow rates, fast cycles and high batch throughput 

✅ Low backpressure at high linear velocities for large-volume feed streams

 ✅ Gentle separation preserves AAV capsids and supercoiled plasmid isoforms 

✅ Effective removal of HCP, gDNA, RNA and endotoxin impurities 

✅ cGMP-ready with traceability, E&L data and validation support for regulatory submission

 ✅ Straightforward scale-up from CIMac / smaller CIMmultus laboratory columns

 ✅ Pre-packed, ready-to-use, minimising packing variability on production floor